This may be too general a question to expect an answer from but here goes..
I am in the process of getting quotes from companies for a 4 page website which has .ne at the front and sql at the back. The site is to be used by medical staff who admit they are not computer experts !
The three designs that have come back are all nice but one of them uses ExtJS desktop which is radically different. ( see dev.sencha.com/deploy/ext-4.0.0/examples/desktop/desktop.html )
I have shown it to some friends and some say thats nice cos its different, others have said why have a website that looks